One thought on “What are Antibodies and What are Antigens?

  1. Arti says:

    During an immune response to a foreign substance, activation of B cells leads to their expansion and formation of plasma B cells which secrete antigen specific antibodies. Antigens are classically defined as any foreign substance that elicits an immune response. Because antibodies are highly specific, they serve as very useful tools in scientific research to elucidate the location, abundance, and function of proteins in dynamic biological systems. However, antigens are structurally complex and consists of multiple antigenic determinants or epitopes. Antibodies recognize foreign invading microorganisms by specifically binding to a pathogen’s proteins or antigens, facilitating their neutralization and destruction. Antibodies recognize foreign invading microorganisms by specifically binding to a pathogen’s proteins or antigens, facil B cell secreted antibodies are predominantly found in the serum fraction of the blood, and serum containing antigen-specific antibodies is often referred to as antiserum. In any given antigen, a B cell will recognize one of a multitude of epitopes, and alternative B cell clones will secrete antibodies specific to alternative epitopes within the same antigen. Antibodies secreted by B cells from the same clone are monoclonal antibodies as they bind specifically to the same epitope. However, the overall humoral response contains antibodies secreted by multiple B cell clone types and is naturally polyclonal.

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